Mark Kleiman is all over the retraction of the ecstasy report--seems there are some problems with Riucarte, the study's principal researcher.

The experiment was purportedly intended to represent in an animal model the consequences of human "recreational" MDMA use, and perhaps of therapeutic use of the drug were it ever approved for that purpose. In the experiment, two out of fifteen animals died. The death rate among human MDMA users is no more than one in a million.

Yet it appears that the researchers failed to investigate the causes of those deaths. Moreover, they went on to draw inferences about the effects of MDMA on humans from the observed damage to the brains of the remaining animals. That didn't seem to trouble the reviewers for Science or the administrators at the National Institute on Drug Abuse who trumpeted the findings as evidence of the dangers of MDMA. (Science is published by the AAAS, whose president, Alan Leshner, was the Director of NIDA when the grant in question was awarded; he made MDMA his particular crusade.)

Our initial report is here.