Report Finds Junk Food and Cocaine Have Similar Brain Effects

A new study finds fatty foods and junk foods cause rats to overeat, triggering the same mechanism in the brain as cocaine.

Doing drugs such as cocaine and eating too much junk food both gradually overload the so-called pleasure centers in the brain, according to Paul J. Kenny, Ph.D., an associate professor of molecular therapeutics at the Scripps Research Institute, in Jupiter, Florida. Eventually the pleasure centers "crash," and achieving the same pleasure--or even just feeling normal--requires increasing amounts of the drug or food, says Kenny, the lead author of the study.


Not surprisingly, the rats that gorged themselves on the human food quickly became obese. But their brains also changed. By monitoring implanted brain electrodes, the researchers found that the rats in the third group gradually developed a tolerance to the pleasure the food gave them and had to eat more to experience a high.

The rats in the study kept eating the junk food even in the face of pain:

They began to eat compulsively, to the point where they continued to do so in the face of pain. When the researchers applied an electric shock to the rats' feet in the presence of the food, the rats in the first two groups were frightened away from eating. But the obese rats were not. "Their attention was solely focused on consuming food," says Kenny.

In previous studies, rats have exhibited similar brain changes when given unlimited access to cocaine or heroin. And rats have similarly ignored punishment to continue consuming cocaine, the researchers note.

I wonder what would happen if, after the rats ate some fattening food, they put some cocaine out next to the food. Would the rats take a little coke, which should make them get un-hungry, and stop eating?

Or, if they gave the rats some coke first, would they'd get un-hungry enough to only eat a little of the junk food?

The study says it's all related to dopamine levels in the brain.

The neurotransmitter dopamine appears to be responsible for the behavior of the overeating rats, according to the study. Dopamine is involved in the brain's pleasure (or reward) centers, and it also plays a role in reinforcing behavior. "It tells the brain something has happened and you should learn from what just happened," says Kenny.

Overeating caused the levels of a certain dopamine receptor in the brains of the obese rats to drop, the study found. In humans, low levels of the same receptors have been associated with drug addiction and obesity, and may be genetic, Kenny says.

Maybe they need to find a time-released "happy pill" that keeps everyone's levels of dopamine at an optimal level.

If you're looking for some healthy foods that raise dopamine production, try bananas, dairy products, pumpkin seeds, almonds and avocados. They raise levels of an amino acid named tyrosine which is a prescursor to dopamine,

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  • Display: Sort:
    That's not exactly new information. Dopamine (none / 0) (#1)
    by tigercourse on Sun Mar 28, 2010 at 05:46:16 PM EST
    is linked to just about everything we find enjoyable.

    Not surprising (none / 0) (#2)
    by andgarden on Sun Mar 28, 2010 at 05:47:10 PM EST
    And as an indirect answer to your question: there is a reason why stimulants like cocaine and amphetamines tend to cause weight loss.

    But this is apparently a really complicated area of the brain. . .

    Oh, and that chocolate cake looks good (5.00 / 1) (#3)
    by andgarden on Sun Mar 28, 2010 at 05:48:12 PM EST
    Too good. ..

    Pleasure... (none / 0) (#4)
    by lentinel on Sun Mar 28, 2010 at 05:49:50 PM EST
    Cocaine induces a pleasurable sensation - or so I've heard.

    What i have also heard that if it is a pure state, it lets the imbiber down gradually.

    When it is mixed with things like amphetamines, it is the withdrawal from those added substances that causes the tremendous anxiety that causes the consumer to take more and more.

    This is another drug that should be considered for re-legalization.

    misprint in title (none / 0) (#5)
    by diogenes on Sun Mar 28, 2010 at 07:50:01 PM EST
    It should be, "Junk science and cocaine have similar brain effects"

    Clearly we need a war on cake (none / 0) (#6)
    by MikeDitto on Mon Mar 29, 2010 at 10:06:47 AM EST
    And introduce a draconian angels food/devil's food sentencing disparity.

    Four more years (in jail)! Four more years (in jail)!

    Wonderful news! (none / 0) (#7)
    by mcl on Mon Mar 29, 2010 at 01:09:41 PM EST
    Now the War on Drugs can expand still further. Look forward to the War On Candy, the War On Cake, the War On Pudding.

    Zealous heavily armed masked agents break down your door, shoot your dog, and point machine guns at you, screaming, "DROP THAT OREO!  DROP IT!! NOW!!!!"